A role for antiviviral medications in the prevention and treatment of HHV-8-associated disease

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A role for antiviviral medications in the prevention and treatment of HHV-8-associated disease

Presenter: Corey Casper. The Department of Medicine, University of Washington, and The Program in Infectious Disease, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Human herpesvirus 8 (HHV-8) is the most recently identified member of the human herpesvirus family and is the aetiologic agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. While highly active antiretroviral therapy has led to impressive declines in the incidence of Kaposi's sarcoma, HHV-8-associated diseases remain common and morbid across the globe. Although comprehensive clinical trials of therapy for HHV-8-associated disease are lacking, numerous studies have found current treatment modalities to be ineffective for many patients. A growing body of basic science and clinical work suggests that antiviral drugs may have a role in the treatment and, more significantly, in the prevention of HHV-8-associated disease. This review discusses the current evidence for the efficacy of antivirals against HHV-8 and proposes a set of novel uses for antiviral medications in the treatment of HHV-8.


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Last Updated : 07/12/2006 12:09:04