HSV for tumour lysis

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Progress in the diagnosis of CMV

Presented by V Emery, Royal Free Hospital School of Medicine, London, UK.

Cytomegalovirus (CMV) remains an important cause of morbidity in the immunocompromised host and in patients with an immature immune system. Thus, solid organ transplant recipients, bone-marrow transplant recipients and HIV-infected individuals, especially those failing highly active antiretroviral therapy, remain at risk of CMV disease. In addition, congenital CMV infection is an important viral cause of CNS abnormalities, including microcephaly and sensorineural deafness. During the last decade, molecular approaches have enabled significant progress to be made in three key areas: understanding CMV pathogenesis in the human host; rapid quantitative diagnostic methods for CMV; and deployment of antiviral chemotherapy. This presentation will review the rapid replication dynamics of CMV in vivo (~1 day), the major role that viral load plays in pathogenesis, and the part that rapid diagnostics assays, such as real time polymerase chain reaction, can play in the prompt initiation of pre-emptive therapy. In addition, I will summarize recent data showing that CMV replication levels prior to, and at the initiation of antiviral therapy, can provide prognostic information on the length of treatment necessary to control CMV in the immunocompromised host.

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Last Updated : 14/04/2004 10:41:28