On-line Learning Zone
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About the
On-line Learning Zone

This section is aimed particularly at busy physicians and other healthcare professionals.

Visitors will find slides and notes from keynote lectures covering a wide range of herpesvirus-related topics. They will also find a diagnostic atlas comprising clinical photographs of herpesvirus infections accompanied by diagnostic notes.

Visitors are welcome to both view and download every file included in this section.

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Diagnostic Atlas Back to contents
Differential diagnoses

Slide 18
Primary chancre caused by syphilis infection*


The most important infectious cause of a differential diagnosis of genital HSV infection is Treponema pallidum infection (i.e. syphilis). This slide shows a primary chancre in a woman. Diagnosis could be made by direct observation of Treponema pallidum using dark ground microscopy, or by the use of serology. It is important to understand that recurrent genital HSV infection and syphilis can co-exist and it is essential that patients with recurrent genital lesions suspected to be due to genital herpes are regularly screened for the acquisition of syphilis. Increases in syphilis incidence have been noted across the developed world, particularly in clusters or outbreaks associated with young homosexual men (sometimes additionally involving HIV transmission). It is essential that surveillance in both sexually transmitted infection clinics, antenatal clinics and other sites for screening sexually active individuals, is maintained to reinforce public health control of transmissions of new cases of syphilis.
* Reproduced by kind permission from: Leibowitch M, Staughton R, Neill S, Barton S, Marwood R. An Atlas of Vulval Disease. 1994. Martin Dunitz, London
www.dunitz.co.uk
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