HSV for tumour lysis

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Modeling herpes prevention: biological and economic considerations

Presented by D Fisman, Drexel University School of Public Health, Philadelphia, USA.

The epidemiology of herpes simplex virus type 2 (HSV-2) is dynamic, with marked changes in prevalence of HSV-2 infection in recent decades. Improved understanding of the epidemiology of HSV-2 transmission, combined with novel tools to control it (e.g. new uses of antiviral drugs and novel tests and vaccines) will permit formulation of more effective disease control programmes. However, adoption of such programmes depends not only on intervention effectiveness, but also on cost-effectiveness. We have constructed mathematical models and performed preference-based research on the impact of genital herpes on health-related quality of life, in order to compare the projected cost-effectiveness of HSV-2 control programmes with that of other commonly accepted health interventions. Using a couple-based simulation to evaluate the cost-effectiveness of testing strategies, we projected that screening of asymptomatic couples for HSV-2 infection would not emerge as a cost-effective health intervention. We are currently using this model to assess the cost-effectiveness of more targeted testing methods. A population-based simulation was constructed to evaluate the economic attractiveness of HSV-2 vaccines. We project that a partially effective vaccine could be a cost-saving health intervention, but that cost-effectiveness depends strongly on the phase of the HSV-2 epidemic in the population of interest.

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Last Updated : 14/04/2004 10:45:21