HSV for tumour lysis

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Modulation of antigen presentation by HSV-1

Presented by J Trgovcich¹, D Lewinsohn², D Johnson², B Roizman³
¹Ohio State University, Columbus, Ohio, USA; ²Oregon Health Sciences University and Portland VA Medical Center, Portland, USA; ³The University of Chicago, Chicago, USA.

Modulation of host immune responses is a common strategy employed by herpesviruses to establish life-long infections. Herpes simplex virus 1 (HSV-1) blocks the MHC class I antigen presentation pathway by inhibiting peptide transport into the endoplasmic reticulum. Relatively few studies have investigated the interaction of viral gene products with the MHC class II pathway. We have shown that wild-type virus infection caused a decrease in the accumulation of class II protein on the surface of cells, and a decrease in the endocytosis. In contrast, we reported that the amounts of cells surface MHC class II proteins were higher in cells infected with the γ134.5 minus mutant, as was the endocytic uptake of fluorescent tracer molecules. We now report that these changes correlate with the ability of infected cells to present antigens to CD4+ T-cells. In contrast, cells exposed to γ134.5 minus mutant were still effective antigen presenting cells. We conclude that HSV-1 gene products alter the capacity of infected cells to present antigens by MHC class II molecules.

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