HSV for tumour lysis

To view some of the files in this section, you will require a version of Adobe Acrobat. This is free to download and is available on the Adobe Acrobat website.

To view the PowerPoint presentations you will require Microsoft PowerPoint. You can download the latest PowerPoint viewer free from the Microsoft website.

You are welcome to download, view and use many of the slides contained in these presentations, however the original presenter and IHMF^Ž must be suitably acknowledged for any use, for example in oral presentations or written material. Please also be aware that some slides contain graphs, illustrations or other content that may not be the copyright of the presenter or the IHMF^Ž and permission ot use such material will need to be obtained from the copyright owner prior to use. Some of the slide presentations from the 13th IHMF^Ž Annual Meeting are subject to 'restricted use' and the presentations to which this applies are labelled with the notice 'Restricted Use - please contact the presenter prior to any use of the content of this presentation'. These 'restricted use' presentations may only be viewed online or downloaded to view, and the original presenter must be contacted prior to any use.

If you are in any doubt about your use of this material, please contact the IHMF Secretariat.

Interactions between HSV and HIV

Presented by S Barton, Chelsea and Westminster Hospital, London, UK.

There is a bilateral synergy between HIV and herpes simplex virus (HSV). Individuals with prior genital HSV infection have an increased risk of acquisition of HIV infection from an HIV-infected partner. Furthermore, individuals infected by HIV who also have genital herpes, appear to have a greater risk of transmitting HIV to an uninfected sexual partner. Individuals with HIV infection who become immunosuppressed with a falling CD4+ count may develop prolonged or severe clinical manifestations of mucocutaneous HSV infection, which is an AIDS diagnostic criteria. Individuals who are immunosuppressed have been reported as developing HSV clinical manifestations with virus resistant to nucleoside analogues. These include thymidine kinase negative mutations, which convey resistance to aciclovir, valaciclovir and famciclovir. An array of clinical management approaches has been described in the literature, from cessation of therapy and topical treatment with agents such as foscarnet, to systemic treatment with agents such as cidofovir or even immune response modifiers such as imiquimod. Clinical guidelines for the management of suspected cases of resistant HSV in immunosuppressed individuals will be presented. There is further interaction between HIV and HSV in co-infected individuals which may create more rapid progression of HIV-related disease due to increased viral replication and immunosuppression. Details of these cellular and immunological effects will be presented. In summary there are clinical and epidemiological as well as intracellular interactions between HIV and HSV. It is clear that a better understanding of the natural history of each infection and how they interact may be pivotal to developing preventative and treatment strategies for both viruses.

View PowerPoint Slide Presentation
PowerPoint Slide Presentation

Download PowerPoint Slide Presentation
Please complete the questionnaire and press the start download button. Your responses will be used by the site maintainers only, to improve the site, and will not be distributed elsewhere. All responses are anonymous and you will not be contacted as a result of submitting the questionnaire.

1.	What is your interest in herpes?
	Physician Other healthcare professional (e.g. nurse, pharmacist, etc) Student in health-related field Person with a herpesvirus infection Friend/loved one of a person with a herpesvirus infection General interest

2.	If you are a 'health professional', please select the most appropriate description of yourself from each of the following two lists.
	What is your occupation? What is your speciality?

The IHMFŽ is a registered trademark of PAREXEL MMS

Last Updated : 14/04/2004 10:43:08